Monticello is a city in and the county seat of Drew County, Arkansas, in the United States. As of the 2010 census, it had a population of 9,467.
Founded in 1849 in the Arkansas Timberlands very near the Arkansas Delta region, the city has long been a commercial, cultural and educational hub for southeast Arkansas. With historical agriculture- and a silviculture-based economy, Monticello has diversified to include growth from the medical sector and the University of Arkansas at Monticello.